5'-O-[(N,N-Diisopropylamino)-(2-Cyanoethoxy)Phosphinyl]-3'-O-(4,4'-Dimethoxytrityl)-Thymidine
5'-O-[(N,N-Diisopropylamino)-(2-Cyanoethoxy)Phosphinyl]-3'-O-(4,4'-Dimethoxytrityl)-Thymidine
CAS: 134031-86-0
Molecular Formula: C40H49N4O8P
5'-O-[(N,N-Diisopropylamino)-(2-Cyanoethoxy)Phosphinyl]-3'-O-(4,4'-Dimethoxytrityl)-Thymidine - Names and Identifiers
| Name | 5'-O-[(N,N-Diisopropylamino)-(2-Cyanoethoxy)Phosphinyl]-3'-O-(4,4'-Dimethoxytrityl)-Thymidine |
| Synonyms | 2'-OMe-U Phosphoramidite 2'-OMe-rU-CE Phosphoramidite 3'-O-DMT-thymidine 5'-CE phosphoramidite 2'-O-Methyl-5'-O-DMT-Uridine-3'-CE-Phosphoramidite 3'-O-(4,4'-Dimethoxytrityl)-thymidine-5'-cyanoethyl-Phosphoramidite 5'-O-[(N,N-Diisopropylamino)-(2-Cyanoethoxy)Phosphinyl]-3'-O-(4,4'-Dimethoxytrityl)-Thymidine 5'-O-[(N,N-DIISOPROPYLAMINO)-(2-CYANOETHOXY)PHOSPHINYL]-3'-O-(4,4'-DIMETHOXYTRITYL)-THYMIDINE 3'-O-[Bis(4-methoxyphenyl)phenylmethyl]thymidine 5'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] |
| CAS | 134031-86-0 |
5'-O-[(N,N-Diisopropylamino)-(2-Cyanoethoxy)Phosphinyl]-3'-O-(4,4'-Dimethoxytrityl)-Thymidine - Physico-chemical Properties
| Molecular Formula | C40H49N4O8P |
| Molar Mass | 744.81 |
| pKa | 9.55±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
5'-O-[(N,N-Diisopropylamino)-(2-Cyanoethoxy)Phosphinyl]-3'-O-(4,4'-Dimethoxytrityl)-Thymidine - Risk and Safety
| HS Code | 29349990 |
5'-O-[(N,N-Diisopropylamino)-(2-Cyanoethoxy)Phosphinyl]-3'-O-(4,4'-Dimethoxytrityl)-Thymidine - Introduction
2 '-OMe-U is a phosphoramidite (phosphoramidite) monomer of 2'-methoxyuridine (2 '-O-methyluridine). The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 2 '-OMe-U phosphoramidite monomer is a colorless or pale yellow solid.
-Molecular formula: C12H18N3O7P.
-Molecular weight: 357.27.
Use:
- 2 '-OMe-U phosphoramidite monomers are commonly used in DNA and RNA synthesis as starting materials to introduce oligonucleotide sequences containing 2'-methoxyuridine modifications.
- 2 '-methoxyuridine modification can improve the stability, anti-nuclease degradation ability and compatibility of nucleic acids, and is commonly used in the research and preparation of double-stranded RNA, anti-RNA interference (RNAi) reagents and antiviral drug research and development.
Preparation Method:
-The method for preparing 2 '-OMe-U phosphoramidite monomer involves a multi-step chemical synthesis, wherein the key step includes reacting 2'-methoxyuridine with phosphoramidite to form a 2 '-OMe-U phosphoramidite ester compound, followed by appropriate protection and purification steps to obtain the final product.
Safety Information:
- 2 '-OMe-U phosphoramidite monomers are generally stable compounds under normal conditions, but laboratory safety procedures must be followed.
-Comply with requirements for chemical storage, fire resistance, corrosion resistance and personal protective equipment during use and handling.
- 2 '-OMe-U phosphoramidite monomer is a chemical. Please store it properly, avoid contact with inflammables, strong oxidants and other substances, and avoid ingestion or inhalation. For accidental contact, rinse immediately with plenty of water and consult a professional doctor.
Nature:
-Appearance: 2 '-OMe-U phosphoramidite monomer is a colorless or pale yellow solid.
-Molecular formula: C12H18N3O7P.
-Molecular weight: 357.27.
Use:
- 2 '-OMe-U phosphoramidite monomers are commonly used in DNA and RNA synthesis as starting materials to introduce oligonucleotide sequences containing 2'-methoxyuridine modifications.
- 2 '-methoxyuridine modification can improve the stability, anti-nuclease degradation ability and compatibility of nucleic acids, and is commonly used in the research and preparation of double-stranded RNA, anti-RNA interference (RNAi) reagents and antiviral drug research and development.
Preparation Method:
-The method for preparing 2 '-OMe-U phosphoramidite monomer involves a multi-step chemical synthesis, wherein the key step includes reacting 2'-methoxyuridine with phosphoramidite to form a 2 '-OMe-U phosphoramidite ester compound, followed by appropriate protection and purification steps to obtain the final product.
Safety Information:
- 2 '-OMe-U phosphoramidite monomers are generally stable compounds under normal conditions, but laboratory safety procedures must be followed.
-Comply with requirements for chemical storage, fire resistance, corrosion resistance and personal protective equipment during use and handling.
- 2 '-OMe-U phosphoramidite monomer is a chemical. Please store it properly, avoid contact with inflammables, strong oxidants and other substances, and avoid ingestion or inhalation. For accidental contact, rinse immediately with plenty of water and consult a professional doctor.
Last Update：2024-04-09 02:00:42
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